"Grey's Anatomy" Season 13 Episode 8 unexpectedly featured a cameo of actor Patrick Dempsey, who impressively portrayed Dr. Derek Shepherd. With his current appearance on the show, fans became hopeful that another beloved character might make a comeback, especially now that the series was reported to focus more on its original characters.

In the said episode, Meredith saw a vivid vision of Derek in front of her after a long, exhausting day at work. Meredith narrated, "How do you keep going? How do you not just sit down and give up? Sometimes it's easy. Sometimes you play games in your head. You make up someone. Someone good. Whatever you need to keep you going."

Although brief, Dempsey's cameo sparked a lot of speculations, especially with regards to original characters reprising their roles. That includes Dr. Cristina Yang, portrayed by none other than Sandra Oh. To recall, Oh's character officially left "Grey's Anatomy" during its Season 10 finale, wherein she accepted a job offer to run a hospital built by her ex, Dr. Preston Burke. Despite the lack of confirmation, fans of the series are still hopeful to see Cristina in the current season.

Many claim that the potential return of Cristina in "Grey's Anatomy" is highly doable considering that her character only moved away unlike Derek who actually died. However, the actress herself already confirmed that she has no plans of returning to the series soon. The real reason behind her exit remains unclear but fans are still hopeful, even for a cameo.

With Dr. Shepherd's cameo, will fans be able to witness Dr. Yang's comeback in "Grey's Anatomy" Season 13? Who else will most likely make a comeback? Find out how things unfold as the hit series airs every Thursday at 8:00 p.m. ET on ABC.