This Gene In Your Body Could Be Blamed For Alcohol Drinking
King's College London, Imperial College London and UT Southwestern Medical Center researchers were able to identify a liver hormone called 'FGF21' which may regulate alcohol consumption by acting directly on a receptor in the brain.
Dr. David Mangelsdorf, UT Southwestern's Chair of Pharmacology and author of the study said: "The findings are based on the largest genome-wide association meta-analysis and replication study to date mapping and comparing the genetics - the DNA - of more than 105,000 light and heavy social drinkers."
When Gene Was Removed, Alchol Intake Increased
Using mice during the study, the researchers found that normally, FGF21 inhibits alcohol preference. A gene variant, β-Klotho, which is seen in approximately 40 percent of people, is associated with a alcohol drinking. When researchers removed β-Klotho from the mice, alcohol intake increased. This means that FGF21's alcohol effects depend on β-Klotho's expression in the brain.
Dr. Mangelsdorf said: "They asked us to conduct experiments in mice to better understand the role of β-Klotho in alcohol drinking behavior. The β-Klotho gene directs the production of the β-Klotho protein that forms part of a receptor complex in the brain."
The Study Could Lead To Drug Development To Regulate Alcohol Consumption
In their report, the researchers said that "excessive alcohol consumption is a major public health problem worldwide, causing an estimated 3.3 million deaths in 2012." Too much alcohol drinking increases risk of many types of illnesses, including liver cancer and heart problems. The results of this research could be used to develop drugs to limit alcohol consumption.
Dr Sidarth Wakhlu, Head of UTSW's addiction division said: "The current study suggests that the FGF21-beta-Klotho pathway regulates alcohol consumption in humans and seems to point to a mechanism that we might be able to influence in order to reduce alcohol intake. If we are able to identify people with heavy, unhealthy or alcohol use disorders who have this genetic variant, we can specially target this complex."
Poor Diet Leading Cause For Heart Disease And Stroke Deaths
Poor diet has been known to lead to more diseaes over time. A poor diet is the leading cause for health disease and stroke deaths.
Too Much Bacon, Soda and Too Little Nuts Linked To Highest Deaths in the US
A new study published in the Journal of the American Medical Association reveals that many Americans die annually from consuming too much bacon and soda and too little nuts and seeds. The study cited a 2012 government report that revealed about 700,000 people died that year from complications resulting from unhealthy eating habits. A combined list of 10 unhealthy ingredients was found to contribute to nearly 45% of these deaths.
Fasting Diet Miracle: 5-Day Calorie Restriction Lowers Risk For Major Diseases
Researchers are calling a healthy fasting diet a miracle due to its amazing capability of lowering major chronic diseases including cancer and diabetes. A specifically designed diet that mimics fasting could be the answer to all our health problems.
General Vaccine For Cancer Not Likely
The search for a general cure for cancer is still being done. A general vaccine for cancer is not yet likely.
A Pint Of Beer A Day Can Increase The Risk For Your Heart
With the number of beer lovers all around the world, could your love for beer pave the way for your health problem in the future? What’s the truth behind claims that consuming a pint of beer a day can actually increase your risk of developing heart problems? Find out what health professionals have to say
The Power Of Cannabis Sheds Light In The Fight Against Brain Cancer
Considering that a lot of US’ states have been considering the legalization of cannabis and others have already been legalizing it, what’s the truth behind new claims that it can potentially be used as the secret weapon against brain cancer? Could it be the cure that can pave the way for other treatments involving cannabis? Find out what experts have to say about it
MORE IN ITECHPOST
Apple Is Targeting Android Users To Switch To iPhone With New Ads
Apple has also revamped its apple.com/switch microsite alongside the new campaign to turn Android users into iPhone owners. Both the video descriptions and the updated microsite highlight Apple’s Move to iOS app for Android.
'Tokyo Ghoul' Season 3 Delayed By Its Live-Action Movie? Ken Kenaki Returns With Another Identity?
"Tokyo Ghoul" season 3's release is delayed and there are countless speculations as to why it is being pushed back. Reports claim that the show is to give way to "One Punch Man" and "My Hero Acdemia" but new rumors say that it's lack of materials and storyline as well as its live-action movie are causing the delay.
Platinum Games Teases New IP In Development
Action games developer Platinum Games has hinted it is working on a new IP along with a new game director.