HIV Drugs May Cause Forgetfulness, Behavioural Changes, New Research Shows
A recent study conducted in the US shows that antiretroviral drugs may take a toll on the brain. Researchers say that these medicines may cause forgetfulness, confusion and behavioural changes.
HIV Drugs Lead To Peptide Beta Amyloid, Often Linked With Alzheimers
University of Pennsylvania researchers were able to gather evidence to implicate that antiretroviral drugs may contribute to HIV-associated neurocognitive disorders (HAND). They suggested that certain protease inhibitors, among the most effective HIV drugs, lead to the production of the peptide beta amyloid, which is often linked to Alzheimer's disease.
According to Economic Times, these drugs prompt an increase in levels of the enzyme that cleaves the amyloid precursor protein, APP, to produce beta amyloid, which is responsible for the damage to neurons.
Kelly Jordan-Sciutto, professor at University of Pennsylvania, said: "Protease inhibitors are very effective antiviral therapies, but they do have inherent toxicities. Our findings may cause us to rethink how we're using these drugs and even consider developing an adjunctive therapy to reduce some of these negative effects."
Protease Inhibitors Are Widely Used In Africa
Out of the 34 million HIV-positive people worldwide, 69% live in sub-Saharan Africa. HIV drugs with protease inhibitors are widely used in the region.
It has already been reported in a previous study that protease inhibitors can have toxic effects on the central nervous system. They trigger the activation of stress-response pathways, including oxidative stress and a process called the unfolded-protein response, or UPR.
Meanwhile, another HIV treatment is also said to endanger the brain. The strategy, which is known as "shock and kill" works by using a so-called latency-reversing agents to wake up dormant viruses in the body, making them vulnerable to the patient's immune system. The idea is that this, in combination with antiretroviral medicines, would wipe out the majority of infected cells. According to a study, this treatment could cause brain inflammation.
Want To Reduce Dementia Risks? Visit The Sauna Often, Study Suggests
According to a recent study, men who visits the sauna 4-7 times a week were 66% less likely to be diagnosed with dementia.
HIV And Alzheimer’s Disease Will Soon Be The Same, But How Is That Possible?
With the growing cases of HIV and Alzheimer’s cases across the globe, how can the two diseases be the same and how are they associated with each other? Find out what health experts have to say
Many People Prone To Remembering Things That Never Happened
Memories can be fleeting. This has been show by a new research, which shows many people are prone to remembering things that never happened.
Caffeine May Help Lower Risk For Dementia
Coffee lovers rejoice as science has proven an important function of caffeine to the brain. Researchers say that it may help in effectively lowering the chances of developing dementia.
Sleeping Too Much Can Be Damaging For Mental Health, New Study Suggests
Considering that the average person needs 7 to 8 hours of sleep, how can a longer duration of sleep affect ones mental health? What are the adverse effects of excessive sleeping that scientists consider as mentally damaging? Is it that serious for it to be associated with mental health? Find out what experts have to say
HIV, The Next Target Of Trump Administration
As continuous efforts to eradicate HIV are taking place, why does the Trump administration wanted to halt the treatment that has been started by the previous government? What’s the truth behind claims that if the current US President would push this through, it will kill thousands? Find out what authorities have to say
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