HIV Cure: Combination Of 3 Antibodies Completely Suppress HIV
A combination of three antibodies might be the next effective HIV cure. Researchers at Rockfeller University revealed an antibody combination which completely suppressed HIV in infected mice. A failure in some HIV treatments is due to virus ability to mutate and dodge the immune system, however, the finding with this new method reveals that the virus eventually run out of options and dies.
HIV infection is characterized by failure of the immune system. With time, HIV develops to AIDS in some patients as the virus evolves beyond the body's capacity to control it. In this condition, the progressive immune system failure allows deadly infections to thrive. However, a small group of infected patients, the so-called elite controllers, has the capability to defeat the virus. This is accomplished using neutralizing antibodies.
In a paper published in Science Translational Medicine, researchers used antibodies from these elite controllers to defeat the virus in mice which immune system are modified to resemble that of humans. They administered three antibodies -- BG18, NC37, and BG1 -- to HIV infected mice. "Some people with HIV produce these antibodies, but most of the time the virus eventually escapes them through mutations in the antibody's corresponding epitope," Natalia Freund first author of the study said in a press release from Rockfeller University.
Freund compared the relationship of antibodies to a tug of war. Some virus escape the antibodies by mutating and continue to grow. Even after years, the body produces new neutralizing antibodies but the virus escapes again. The study reveals that after several rounds of escaping from the administered antibodies, the virus eventually run out of options.
Three weeks after the combination of the antibodies where given to the mice, test results revealed that the virus was undetectable in about 66 percent of the mice. "This study validates the approach of using three different antibodies to control HIV infection," Freund said. She added that this could open a path for a new HIV cure.
Diabetes Reversed In Mice Through Interspecies Transplant
Rat and mouse hybrid gives hope for more effective diabetes treatment. The interspecies animal could also be the answer to the shortage of human organ donors.
Alzheimer's Treatment: Drug Compound Can Reverse Neurological Damage
Scientists found a drug compound for new Alzheimer's treatment. It can halt or even reverse neurological damage by controlling tau protiens. It has been tested in mice and monkeys and a clinical trial for human patients are underway.
Rare Alien-like Insect Placed In Its Own Scientific Order
Ancient alien-like insect with triangular head placed in a new species, genus, family and order. The tiny yet scary-looking species lived together with dinosaurs about 100 million years ago.
HIV, The Next Target Of Trump Administration
As continuous efforts to eradicate HIV are taking place, why does the Trump administration wanted to halt the treatment that has been started by the previous government? What’s the truth behind claims that if the current US President would push this through, it will kill thousands? Find out what authorities have to say
How Do We Reduce HIV Risk? Here Are Experts' Tips
With the continuous efforts to eradicate one of the world's long dreaded disease, can we really do certain precautionary measures to prevent the risk of HIV? What are the necessary steps to prevent transmission of the disease? Find out what experts have to say
HIV Vaccine Cures Five Patients For Seven Months
New AIDS vaccine developed in Spain have reportedly cured 5 patients, helping them remain virus-free for seven months after taking the treatment. In the study, the treatment allowed the patients to stop taking regular antiretroviral (ARV) drugs to suppress HIV symptoms.
MORE IN ITECHPOST
Welcome To InsurTech: The Next Generation of Insurers
With how quickly technology has advanced in the past couple of decades, it's no wonder that it is changing many industries as we know it. Insurtech is sure to give insurance companies a new look and a modern business model to go by.
How Do Personal Emergency Response Systems Work?
Personal emergency response systems, known as PERS for short, are systems that help people to raise the alarm and get immediate help when a medical or personal emergency occurs. They are ideal for older people and anyone with a mobility issue or an injury or illness that can cause falls.
Game Developers’ Different Roles in the Studio
Learn about the different professionals involved in developing video games. Becoming a game developer is one of the coolest jobs around and your 14-year-old self, perched on the edge of your bed as you play PlayStation, will thank you for making such an awesome career move.
Surviving Your First Year of College
You Did It! You’re Off to College! Congratulations! You have finished high school and are off to college. The sense of accomplishment is overwhelming, and you have not even graduated yet! However, beware of the pitfalls. The allure of going to college is often associated with one word—freedom. You are leaving home to be on your own. You can have all the friends you want, stay up as late as you want, and perhaps spend as much money as you want. If you keep your head, you can avoid the problems associated with college life.