Cancer Drugs Helps Weight Loss Even With High-Fat Diet
The key to treating obesity was accidentally found! A study which originally aimed to investigate the impact of obesity in cancer treatment led to an unexpected discovery. Researchers at Mayo Clinic in Arizona found out that two common anti-cancer drugs can effectively help in weight loss even with a high fat diet.
Obesity refers to the condition in which a person has too much body fat to the point that it negatively affects the person's health. It is commonly caused by too much food intake, lack of physical activity, and genetic susceptibility. The main treatment for obesity is exercise and good diet, however, there are also medications and surgery to help manage obesity.
In a study published in Oncotarget on Tuesday, Jan 17, researchers used anti-cancer drugs on morbidly obese mice. Instead of just targeting cancer, methotrexate and cyclophosphamide helped remove excess fats on the mice. The researchers added that the medicines can be dosed without detectable toxicity to obese patients without cancer. Methotrexate and cyclophosphamide are also currently used to treat some noncancerous conditions including rheumatoid arthritis.
The researchers highlighted that the weight loss in mice was not attributed to increased energy expenditure, malabsorption or decreased food intake. In fact, the mice continued to have high-fat diet in the duration of the study. The methotrexate or cyclophosphamide depleted the fat cell precursors in the mice which led to much decreased fat storage.
"Based on our composite data it appears that methotrexate or cyclophosphamide can induce the livers of obese mice to burn off rather than accumulate excessive dietary fat. This results in desirable weight reduction instead of increased obesity, even with continued caloric binging," Dr. Sandra Gendler, co-author of the study said in a press release from Mayo Clinic. She added that the use of anti-cancer drugs would help the weight loss of morbidly obese patients who have troubles in restraining their food intake.
Cancer Treatment: Best Therapy Found On Cancer's Genetic Script
Researchers create a tool which gives doctors the best personalized cancer treatment options for patients based on their genetic features.
Yellow Fever Outbreak In Brazil Kills 30, Officials Fear Epidemic
A yellow fever outbreak in Minas Gerais State in southeastern Brazil infected about 110 people and killed 30. Officials fear it might turn to an epidemic.
Schizophrenia Directly Linked To Diabetes
Diabetes risk increases upon onset of schizophrenia. Even removing other factors like diet, exercise and effects of antipsychotic drugs.
Fasting Diet Miracle: 5-Day Calorie Restriction Lowers Risk For Major Diseases
Researchers are calling a healthy fasting diet a miracle due to its amazing capability of lowering major chronic diseases including cancer and diabetes. A specifically designed diet that mimics fasting could be the answer to all our health problems.
General Vaccine For Cancer Not Likely
The search for a general cure for cancer is still being done. A general vaccine for cancer is not yet likely.
MORE IN ITECHPOST
Best Traveling Apps for Smartphones
Apps for mobile devices led personal, independent traveling to a new level. Nowadays, your pocket can easily fit all the possibilities of a small tourism agency. GPS, maps, currency calculators, city guides, dictionaries, hotel search services, etc. The right set of apps for traveling helps in planning your journeys and saving time, money, and nerves while you sit in a café or taxi, or lie in bed.
How Do Personal Emergency Response Systems Work?
Personal emergency response systems, known as PERS for short, are systems that help people to raise the alarm and get immediate help when a medical or personal emergency occurs. They are ideal for older people and anyone with a mobility issue or an injury or illness that can cause falls.
The 9 Most Popular (And Fun) Internet Games of 2019
Are you bored of board games? What are the most popular internet games from this year? These nine are popular for a reason. Check 'em out!