Parkinson's Disease: Researchers Discover Genetic Switch
Parkinson’s disease is a disease of the nervous system, affecting middle-aged and elderly people. Researchers discovered that a gene called ATF4 could possibly act as a switch of genes that could control mitochondrial metabolism for neuron health. Dr Miguel Martins, lead researcher explained that when the expression of ATF4 is reduced in flies, expression of these mitochondrial genes drops. This drop results in dramatic locomotor defects, decreased lifespan, and dysfunctional mitochondria in the brain.
In addition to this when these mitochondrial genes were over exposed, mitochondrial function was restored, and neuron loss was avoided. Researchers have singled out new therapeutic targets that could prevent neuron loss. By determining the gene networks that organize this process.
Parkinson’s disease has several forms, some of which are called PINK1 and PARKIN. These are assisting in mitochondrial quality control. Fruit flies with alterations in these genes accrue abnormal mitochondria and exhibit Parkinson's-like changes, including loss of neurons.
The researchers used mutant flies with PINK1 and PARKIN to investigate other critical Parkinson's genes. They also used bioinformatics approach discovering that the ATF4 gene is an important aspect. According to the Meical News Today, Dr. Martin said that contemplating on these genes and their role in the human neurons could surpass creations of possible delays or prevention of the neuronal loss seen in Parkinson's disease.
The research results of the University of Leicester team, discovered various genes that take care of neurons in Parkinson's disease. This has opened potential creation of effective treatment alternative. According to the Science Daily, PINK1 and PARKIN, affect how mitochondria break down amino acids to generate nucleotides. They are in charge of the metabolism of these molecules generates the energy that cells need to live. The researchers believe that they have found several new ways that could potentially cure Parkinson’s disease.
Scientist Develops Wonder Materials For Flexible And Durable Gadgets
Scientists develop wonder materials to improve the durability and efficiency of gadgets. This wonder material could enhance the flexibility of the gadgets.
Scientist Plans To Recreate Woolly Mammoths In Artificial Womb
Woolly mammoths have been extinct for about 4000 years ago. Harvard scientists claim that they are close to creating woolly mammoth embryo.
Rare Leptospirosis In New York And The Things You Should Know
Rare leptospirosis cases were recorded in New York. CDC informs people of the symptoms and the ways to prevent acquiring it. It may be fatal if not treated immediately.
Deep Brain Stimulation Shows Potential In Anorexia Therapy
Considering the continuous efforts to spread awareness to the adverse effects and the nature of Anorexia, have scientists just found the answer to the said medical condition? What's the truth behind claims that deep brain stimulation is allegedly showing promising results in anorexia therapy? Here's what experts have to say
Blood Test: An Early Detection Agent For Parkinson’s Disease, New Study Claims
Just as you thought Parkinson’s disease was undetectable, what’s the truth behind claims that a simple blood test can determine if you are at high risk for Parkinson’s? What component is there in our blood that it can be used to predict the disease? Here’s what health professionals have to say
Iron Overload In Babies May Lead To Parkinson's Disease
Recent studies have comfirmed that iron overload in childhood may play a role in the development of Parkinson's disease. The discovery is important in developing a test that can measure potential for the disease as early as possible, and also to make parents aware of the effects of too much iron in their children.
MORE IN ITECHPOST
Best Traveling Apps for Smartphones
Apps for mobile devices led personal, independent traveling to a new level. Nowadays, your pocket can easily fit all the possibilities of a small tourism agency. GPS, maps, currency calculators, city guides, dictionaries, hotel search services, etc. The right set of apps for traveling helps in planning your journeys and saving time, money, and nerves while you sit in a café or taxi, or lie in bed.
How Do Personal Emergency Response Systems Work?
Personal emergency response systems, known as PERS for short, are systems that help people to raise the alarm and get immediate help when a medical or personal emergency occurs. They are ideal for older people and anyone with a mobility issue or an injury or illness that can cause falls.
'The Outer Worlds' Pre-Order Guide Plus Game Details Roundup
"The Outer Worlds" is only days away, and fans can pre-order the game.
Advantages of Team Sports for Students
Most students are aware that physical exercise is a beneficial activity that does not only improves physical and mental health but also provides plenty of more benefits. Good fitness, energy, focus, self-discipline - these are just some of the few listed advantages from a significantly bigger list.