Parkinson's Disease: Researchers Discover Genetic Switch
Parkinson’s disease is a disease of the nervous system, affecting middle-aged and elderly people. Researchers discovered that a gene called ATF4 could possibly act as a switch of genes that could control mitochondrial metabolism for neuron health. Dr Miguel Martins, lead researcher explained that when the expression of ATF4 is reduced in flies, expression of these mitochondrial genes drops. This drop results in dramatic locomotor defects, decreased lifespan, and dysfunctional mitochondria in the brain.
In addition to this when these mitochondrial genes were over exposed, mitochondrial function was restored, and neuron loss was avoided. Researchers have singled out new therapeutic targets that could prevent neuron loss. By determining the gene networks that organize this process.
Parkinson’s disease has several forms, some of which are called PINK1 and PARKIN. These are assisting in mitochondrial quality control. Fruit flies with alterations in these genes accrue abnormal mitochondria and exhibit Parkinson's-like changes, including loss of neurons.
The researchers used mutant flies with PINK1 and PARKIN to investigate other critical Parkinson's genes. They also used bioinformatics approach discovering that the ATF4 gene is an important aspect. According to the Meical News Today, Dr. Martin said that contemplating on these genes and their role in the human neurons could surpass creations of possible delays or prevention of the neuronal loss seen in Parkinson's disease.
The research results of the University of Leicester team, discovered various genes that take care of neurons in Parkinson's disease. This has opened potential creation of effective treatment alternative. According to the Science Daily, PINK1 and PARKIN, affect how mitochondria break down amino acids to generate nucleotides. They are in charge of the metabolism of these molecules generates the energy that cells need to live. The researchers believe that they have found several new ways that could potentially cure Parkinson’s disease.
Scientist Develops Wonder Materials For Flexible And Durable Gadgets
Scientists develop wonder materials to improve the durability and efficiency of gadgets. This wonder material could enhance the flexibility of the gadgets.
Scientist Plans To Recreate Woolly Mammoths In Artificial Womb
Woolly mammoths have been extinct for about 4000 years ago. Harvard scientists claim that they are close to creating woolly mammoth embryo.
Rare Leptospirosis In New York And The Things You Should Know
Rare leptospirosis cases were recorded in New York. CDC informs people of the symptoms and the ways to prevent acquiring it. It may be fatal if not treated immediately.
Deep Brain Stimulation Shows Potential In Anorexia Therapy
Considering the continuous efforts to spread awareness to the adverse effects and the nature of Anorexia, have scientists just found the answer to the said medical condition? What's the truth behind claims that deep brain stimulation is allegedly showing promising results in anorexia therapy? Here's what experts have to say
Blood Test: An Early Detection Agent For Parkinson’s Disease, New Study Claims
Just as you thought Parkinson’s disease was undetectable, what’s the truth behind claims that a simple blood test can determine if you are at high risk for Parkinson’s? What component is there in our blood that it can be used to predict the disease? Here’s what health professionals have to say
Iron Overload In Babies May Lead To Parkinson's Disease
Recent studies have comfirmed that iron overload in childhood may play a role in the development of Parkinson's disease. The discovery is important in developing a test that can measure potential for the disease as early as possible, and also to make parents aware of the effects of too much iron in their children.
MORE IN ITECHPOST
Facebook is Launching a Dating App in the U.S.
Facebook announced early in September that it will be rolling out its latest service in the U.S.: a dating platform. Known as Facebook Dating, the platform can be accessed via the Facebook app.
New Retroreflective Material Could be Used in Nighttime Color-Changing Road Signs
BUFFALO, N.Y. -- A thin film that reflects light in intriguing ways could be used to make road signs that shine brightly and change color at night, according to a study that will be published on Aug. 9 in Science Advances.
Top 5 Video Games to Play for a Truly Unique First Date
Video games have a way of taking us outside of ourselves and live in a fantasy world. It's even better when you're playing a game with someone special!