Cancer Cure: Drug To Starve Cancer Cells To Death Identified In Study
Scientists reveled a more efficient cancer cure. In a recent study, researchers found a way to exploit the weak points of tumor cells through their metabolic defect, that is, by forcing them to reveal their fuel supply and starving them to death. They have also found a drug for this new treatment and are now planning a clinical trial.
Scientists have been trying to find ways to block nutrients from reaching tumor cells for decades. A saracoma cell relies on its environments for arginine, a protein which is an important building block in cells. Blocking these would result to starvation or proliferation of the tumor cells. However, previous efforts for this kind of treatment resulted to failure due as the cells had numerous back-up routes.
In a study published in in Cell Reports on Tuesday, Jan. 24. Researchers at Washington University School of Medicine in St. Louis (WUSTL) investigated mice which were implanted with tumor samples of human patients. They were able to map these back-up routes and identified a drug to block them. Previously, sarcomas are treated through chemotherapy, radiation and surgery but these traditional treatments are often deemed ineffective.
"When we use a drug to deplete arginine in the blood, the cancer cells panic because they've lost their fuel supply. So they rewire themselves to try to survive. " Brian A. Van Tine, MD, PhD, senior author of the study said in a press release from WUSTL. "In this study, we used that rewiring to identify drugs that block the secondary routes."
The researchers also highlighted that this treatment method would be less toxic. Unlike other cancer cure, this method would not affect healthy cells. Normal cells make their own arginine so they would not be affected by the starvation. They added that by completely shutting down the tumor metabolism resulted to shrinking of the tumors.
Currently, researchers at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine are planning to do a clinical trial of the arginine-depleting drug. Van Tine explained that the drug will be the baseline of the trial but they would also add other therapies. If effective, he added that this new cancer cure could treat about 90 percent of sarcoma tumors.
Brain Surgery Made Safer With New Smart Needle
A new medical technology, smart needle, has a fiber optic camera which can help surgeons identify risky blood vessels during brain surgery.
Alzheimer’s Disease: Early Memory Loss Can Be Reversed By Music
A new clinical study reveals listening to music and simple meditation can reverse early memory loss. It can also improve well-being and quality of life for elders with preclinical Alzheimer’s disease
Leukemia Treatment: New Combination Of Drugs To Battle Blood Cancer
Study revealed that combining obinutuzumab with TLR7 activation can enhance survival of mice with blood cancer. Researchers are now using this combination for developing leukemia treatment.
Fasting Diet Miracle: 5-Day Calorie Restriction Lowers Risk For Major Diseases
Researchers are calling a healthy fasting diet a miracle due to its amazing capability of lowering major chronic diseases including cancer and diabetes. A specifically designed diet that mimics fasting could be the answer to all our health problems.
Medical Experts Offer Free Colon and Rectal Cancer Screening Advice
People above the age of 50 years have been advised to go for colon cancer screening every 10 years to forestall developing colon cancer. African-Americans are advised to do the screening from age 45 years above. While people with a family history of colon cancer are advised to begin the screening at a much earlier age – since the earlier colon cancer is discovered, the easier it is to remove its tumor.
MORE IN ITECHPOST
No More Browser For Facebook Messenger: Windows and Mac Desktop App With Video Chat Is Here!
Facebook has just recently announced that the Facebook Messenger app for both Windows and Mac is finally here!
Biogenerators Solve Oxygen and Organic Matter Problems Taking Humanity One Step Closer to the Colonization of Mars
Elon Musk's SpaceX along with NASA has been really open about their objectives to colonize Mars and now with the new biogenerators, humanity now takes one step forward!
London Startup Company Brings the Virtual Reality Gaming Chair to Life!
A local London startup company has brought a gamer's dream to life by creating a virtual reality gaming chair!