Genetically Engineered Spider Toxin Becomes A Vaccine
Researchers have come up with an ingenious solution to the nuisance caused by spiders and their toxic venom.
By genetically modifying the spider toxin, researchers have now developed a vaccine. Since the genetically engineered version consists of three proteins, it is expected to provide protection against more than one type of toxin. Further, the new product does not have any side effects on the immunized animal which produces the vaccine. It is also supposed to be more effective than the crude venom from spiders. Tests on rabbits showed immune response similar to the entire toxin, but without any of the toxic side effects. The engineered version was protective against the poison from the L. intermedia and L. gaucho sub-species. The immunized rabbits showed protective effect after being tested with the Peruvian spider Loxosceles laeta venom (PLlv) and L. laeta venom from Brazil (BLlv). "In vitro assays with horse anti-loxoscelic antivenoms produced in Brazil and Peru demonstrated that these commercial antivenoms were efficient to inhibit the sphingomyelinase activity of PLlv and BLlv, " the investigators led by Dr. Chávez-Olortegui of the Departamento de Bioquímica e Imunologia, at the Universidade Federal de Minas Gerais (Brazil) write.
"It's not easy taking venom from a spider, a snake or any other kind of venomous animal," said Chávez-Olortegui, in his interview with Eureka News. "With our new method, we would be able to engineer the proteins in the lab without having to isolate whole toxins from venom. This makes the whole process much safer."
"Existing anti-venoms are made of the pure toxins and can be harmful to people who take them. We wanted to develop a new way of protecting people from the effects of these spider bites, without having to suffer from side-effects."
The research is an advance over the current practice of using animals to generate the vaccines: administering the venom to animals, and taking the resulting antibodies for the serum. The genetic engineering approach obviates the need for animal experimentation and the consequent toxic effects animals are subjected to.
By identifying unique proteins or peptides and raising antibodies the researchers are able to neutralize some of the biological effects induced by crude spider venom, demonstrating a protection against the venom. The research paves the way for the development of therapeutic vaccines against spider venom, on a larger scale. Using similar genetic engineering approaches, the researchers led by Chávez-Olortegui have previously developed Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom, and is currently in pre-clinical stages.
Russian Spies Have Been Targeting Organisations Researching Coronavirus Vaccines
It seems like spies from Russia are targeting organizations that are trying to conduct coronavirus vaccine research.
Only 8 Were Found To Have Coronavirus Antibodies Out of 986 Tested in Colorado Using Finger-Prick Device
Several Health Departments are now conducting tests to find hosts of Coronavirus Antibodies to aid in the fight against the pandemic.
[VIDEO] Second 'Skin Deep' Vaccine Backed by Bill Gates Begins Testing: Do We Finally Have a Successful One?
The Bill Gates Foundation has backed up the second vaccine candidate which is now 'skin deep' instead of the previous deep jab. Will this be the final vaccine?
Diabetes News: Virus Found In Feces Linked To Diabetes Type 1
The latest on diabetes news confirms that virus from feces has been definitively linked to the development of type 1 Diabetes. The study opens up the oppotunity to developm a vaccine to preven the disorder in the near future.
Anti-vaccine Claims Made By Doctor Creates Chaos Among Medical Practitioners
Doctor who made anti-vaccine claims caused chaos among medical practitioners.
MORE IN ITECHPOST
How to Get More Life Out of Your PC -- Even If It's Already Old
Computers are expensive, so it makes sense to take good care of yours. Ideally, you'd take great care of your PC from the beginning -- cleaning it regularly with canned air, being careful with it, and protecting it from power surges, heat, and drops or falls.
2 NASA astronauts are home from ISS, proving SpaceX can safely bring people to and from space
After a two-month mission, SpaceX brings back home 2 astronauts, proving that it could transport people to and from space safely.
Something is Surely Brewing Within Destiny 2
How are you keeping on? There's a whole lot of content in the game and even though some of it is going away, the great variety won't go anywhere. On top of that, new stuff will be added and the huge add-on announced not that long ago kind of gives you hint about that. If you've played this game long enough, then you know you can't have everything, but what if there was a way? Of course, we're talking about Destiny 2 boosting. But it's not just good for herding some items. Our services can be used for any in-game goal, small or big.